MP-SPR用于生物传感器开发

在食品和饲料安全、环境安全、临床诊断、边境控制和过程控制等领域，MP-SPR是一种非常有价值的分析开发工具。虽然世界范围内的部分研究致力于高通量仪器，但便携式或即时诊断设备越来越受到关注。MP-SPR是开发便携式生物传感器的优秀工具。便携式生物传感器通常包括电化学传感器、表面增强拉曼传感器（SER）、酶联免疫吸附试验（ELISA）、荧光或最近的印刷诊断。

选择MP-SPR进行分析开发的五个原因：

1、SPR传感器易于非原位修饰
2、任何分析类型
3、任何样品
4、易于验证
5、微流体材料测试

有关电化学生物传感器开发的信息，请单击此处。

MP-SPR可以回答的五个分析开发中的关键问题：

1、与表面B相比，分子X与表面A结合的速度有多快？

2、我的生物传感器应用的最佳表面是什么？

3、我的化验是如何处理诸如血清、唾液、海水或尿液之类的原始样本的？

4、我设计的生物传感器是否比前一个更有效？

5、哪种涂层可以防止样品吸附到我的微流体通道上？

BioNavis_AN#117_使用SPR Navi 200定量分析单链寡核苷酸

BioNavis_AN#126_使用MP-SPR研究纤维素模型表面与蛋白质的相互作用

BioNavis_AN#131_使用MP-SPR技术的深扫描光学现象测定微米尺度层的光学特性和相互作用

BioNavis_AN#132_通过MP-SPR测定功能层的结合能力

BioNavis_AN#140_使用MP-SPR测量自组装金纳米粒子

BioNavis_AN#145_使用MP-SPR研究病毒之间的相互作用

BioNavis_AN#150_使用MP-SPR表征有机膦酸盐

BioNavis_AN#151_ MP-SPR测量100%血清中纳米粒子上的恒定蛋白冠和动态蛋白冠

BioNavis_AN#160_生物传感器用于检测奶粉中的细菌

Selected publications:

For electrochemical sensor development using MP-SPR, click here.

Printed biosensor development using MP-SPR:

• An impedimetric study of DNA hybridization on paper-supported inkjet-printed gold electrodes, Ihalainen P et al., Nanotechnology, 25, 9, 2014
• Application of Paper-Supported Printed Gold Electrodes for Impedimetric Immunosensor Development, Ihalainen P et al., Biosensors 2013, 3, 1-17

MEMS sensor development using MP-SPR:

• Investigation of pH-Induced Protein Conformation Changes by Nanomechanical Deflection, Thakur G et al., Langmuir, 2014, 30 (8), pp 2109–2116

Novel coatings to avoid non-specific binding using MP-SPR:

• Surface Plasmon Resonance on Nanoscale Organic Films, Albers MW and Vikholm-Lundin I, Nano-Bio-Sensing, 1st ed, Chapter 4, Springer 2010
• Grafting hyaluronic acid onto gold surface to achieve low protein fouling in surface plasmon resonance biosensors, Liu X et al, ACS Appl Mater Interfaces. 2014 Aug 13;6(15):13034-42
• Effects of Composition of Oligo(ethylene glycol)-Based Mixed Monolayers on Peptide Grafting and Human Immunoglobulin Detection, Islam N et al.,  Journal of Physical Chemistry, 2014, 118 (10), pp 5361–5373

Assay development using MP-SPR:

• Dynamic and equilibrium performance of sensors based on short peptide ligands for affinity adsorption of human IgG using surface plasmon resonance, Islam N et al., Biosensors and Bioelectronics, 58, 2014, p. 380-387
• Rapid and sensitive detection of maize chlorotic mottle virus using surface plasmon resonance-based biosensor, Zeng C et al., Anal. Biochem. 440 (2013) 18–22
• Development of diagnostic SPR based biosensor for the detection of pharmaceutical compounds in saliva, Sonny S et al., Proc. SPIE 7376, Laser Applications in Life Sciences, 737605
• Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the anti-tumor immunity and efficacy against melanoma, Capasso et al., Taylor & Francis Online, 2015

Improving performance of optical biosensors:

• Label-Enhanced Surface Plasmon Resonance: A New Concept for Improved Performance in Optical Biosensor Analysis, Granqvist N et al., Sensors 2013, 13(11), 15348-15363