MP-SPR in biophysicsInterfaces and membranes such as the cell phospholipid membrane and mitochondrial membrane have important biochemical and biophysical roles aside of being barriers. Moreover, membranes contribute as microenvironment to synthesis and catalysis reactions, and the cell membrane also incorporates all the cell signaling components.The biological biomembranes and interactions of analysts with biomembranes are studied in drug development, nanoparticle biological interaction, targeted drug delivery, gene therapy and personalized medicine. Biomembranes are often of great interest in fundamental biochemistry and biophysics research.
See five reasons to choose MP-SPR for biophysics:
- No artifacts from lipid swelling
- Easy lipid membrane formation on variety of substrates
- Membrane quality assessment
- Combination of MP-SPR with electrochemistry
- From measurements on biomembranes to measurements on living cells
See five key questions in biophysics that MP-SPR can answer:
- What is the kinetics of supported lipid bilayer formation?
- How does nanoparticle X interact with a biomembrane?
- How does a membrane protein (such as GPCR) interact with a drug?
- What is the quality (thickness and optical density) of the biomembrane?
- How stable is a membrane system in air?
- Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation, Kari et al., Drug Delivery and Translational Research, 2016
- Role of the Tryptophan Residues in the Specific Interaction of the Sea Anemone Stichodactyla helianthus’s Actinoporin Sticholysin II with Biological Membranes, García-Linares et al., Biochemistry, 2016
- Differential Effect of Membrane Composition on the Pore-Forming Ability of Four Different Sea Anemone Actinoporins, García-Linares et al., Biochemistry, 2016
- Cholesterol stimulates and ceramide inhibits Sticholysin II-induced pore formation in complex bilayer membranes, Alm et al., Biochimica et Biophysica Acta, 2015
- Control of the Morphology of Lipid Layers by Substrate Surface Chemistry, Granqvist et al, Langmuir, 2014
- Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi, Angelo et al. Nature, 2013